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1	Philippine Council for Health Research and Development Library	Box No. 109	Full-text	File	no
2	Philippine Council for Health Research and Development		Full-text	print	no

A biochemical assessment of the anti-inflammation activity of compounds from Philippine Medicinal plants.

Study Details
Location

Author

Mafel C. Ysrael,

Kevin D. Croft

Publication Information

Publication Type

Journal

Publication Sub Type

Journal Article, Original

Title

Acta Manilana

Frequency

Annual

Publication Date

1998

Volume

Page(s)

65-70

Abstract

The prostaglandins (PG's), leukotrienes (LT's) and platelet activating factor (PAF) are potent inflammatory mediators. The PG's and LT's are derived from the oxidative metabolism of arachidonic acid via the cyclooxygenase and lipoxygenase pathways, respectively. Anti-inflammatory agents prevent the formation of these mediators. The selective inhibition of the cyclooxygenase pathway by the non-steroidal anti-inflammatory drug (NSAID's) explain the anti-inflammatory action. The biochemical assessment of compounds for anti-inflammatory activity is based on the ability of very small amount of pure compounds to inhibit the formation of the inflammatory mediators in isolated Ca- ionosphere stimulated rat peritoneal leukocytes. Of the eight pure compounds tested, scandenolide, a sesquiterpene lactone from Mikania cordata (Burm.f.) BL Robinson , showed potential anti-inflammatory activity.

References

1. Salmon, JA , Higgs, GA . Brit Med Bull 43, 285, 1987

2. Vargaftig, BB , Braquet, PG . "Brit Med Bull" 312, 43, 1987

3. Dusting, GJ , MacDonald, PS . Current Therapeutics 27, 27, 1986

4. Bird, J , Giroud, JP . J Pharmacol Mthds 14, 305, 1985

5. Kovacs, IB , Meyrick, TRH , Mackay, AR , Rustin, MHA , Kirby, JDT . Clin Sci 70, 257, 1986

6. Terano, T , Salmon, JA , Moncada, S . Biochem Pharmacol 33, 3071, 1984

7. Mahoney, DP , Barden, A , Beilin, LJ , Vandongen, R . "Prost Leuk Med" 12, 11, 1983

8. Croft, KD , Codde, JP , Barden, A , Vanogen, R , Beilin, LJ . "Life Sciences" 38, 1875, 1986

9. Croft, KD , Sturn, MJ , Codde, JP , Vandongen, R , Beilin, LJ . "Clin Exp Pharm Physiol" 15, 517, 1988

10. Hall, IH , Lee, KH , Starnes, CO , Sumida, Y , Wu, RY , Wadell, TG , Cochran, SW , Gerhart, KG . J Pharm Sci 68, 573, 1979

11. Ivie, GW, Witzel, DA , Keeler, R , Tu, A , Marcel, Dekker . "Encyclopedia Handbook of Natural Toxins. New York" , 543-84, 1983

12. Hall, IH , Starnes, CO , Lee, KH , Sykes, HC . Planta Medica , 153, 1987

13. Hall, IH , Lee, KH , Sykes, HC . Planta Medica 153, 1987

14. Quisumbing, ES . Medicinal Plants of the Philippines. Katha Publishing Company, Quezon City, Philippines , 1978

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Location	Location Code	Available Format	Availability
Philippine Council for Health Research and Development Library	Box No. 109	Fulltext	pdf (Request Document)
Philippine Council for Health Research and Development		Fulltext	Print Format